Homeobox Protein NANOG (NANOG) Antibody

NANOG is a Ttranscription regulator involved in inner cell mass and embryonic stem (ES) cels proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation.

Target	Homeobox Protein NANOG (NANOG)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 94-123 amino acids from the Central region of human NANOG.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9H9S0 (UniProt, ExPASy)
UniProt Secondary AC	D3DUU4, Q2TTG0, Q6JZS5
UniProt Entry Name	NANOG_HUMAN
NCBI Accession	NP_079141.2
String	9606.ENSP00000229307
Molecular Weight	Calculated MW: 34.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow and Monkey NANOG.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Homeobox Protein NANOG (NANOG)

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