N-Acetylneuraminic Acid Synthase (NANS) Antibody

NANS Antibody is a Rabbit Polyclonal antibody against NANS. This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.

Target	N-Acetylneuraminic Acid Synthase (NANS)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 260-359 of human NANS.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NR45 (UniProt, ExPASy)
UniProt Secondary AC	B2RE98, Q8WUV9, Q9BWS6, Q9NVD4
UniProt Entry Name	SIAS_HUMAN
Gene Symbol	NANS
GeneID	54187
NCBI Accession	NP_061819.2
String	9606.ENSP00000210444
Molecular Weight	Calculated MW: 40 kDa Observed MW: 40 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on N-Acetylneuraminic Acid Synthase (NANS)

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