Natriuretic Peptides B (NPPB) Antibody

NPPB Antibody is a Rabbit Polyclonal antibody against NPPB. This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.

Target	Natriuretic Peptides B (NPPB)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000 - 1/5000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 35-134 of human BNP.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P16860 (UniProt, ExPASy)
UniProt Secondary AC	B0ZBE9, Q6FGY0, Q9P2Q7
UniProt Entry Name	ANFB_HUMAN
Gene Symbol	NPPB
GeneID	4879
NCBI Accession	NP_002512.1
KEGG	hsa:4879
String	9606.ENSP00000365651
Molecular Weight	Calculated MW: 15 kDa Observed MW: 14 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	2.21 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Natriuretic Peptides B (NPPB)

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