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NCAM1 Antibody is a Rabbit Polyclonal antibody against NCAM1. Neural cell adhesion molecule 1 (NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin (Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurones, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA (PMID: 9696812). The glycosylphosphatidylinositol (GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronectin-type III repeats (FNIII). All three forms can be posttranslationally modiﬁed by addition of polysialic acid (PSA) (PMID: 14976519). Several other isofroms have also been described.
Research Articles on Neural Cell Adhesion Molecule 1 / CD56 (NCAM1) Antibody
||Neural Cell Adhesion Molecule 1 / CD56 (NCAM1)
||Human, Mouse, Rat
||WB, IHC, FCM
||WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, FCM: 1/20 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
||Recombinant protein of human NCAM1.
||Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
|UniProt Primary AC
||Calculated MW: 40 kDa, 73 kDa, 80 kDa, 83 kDa, 93 kDa, 94 kDa
Observed MW: 120 kDa
||PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
||> 1 mg/ml
||Shipped within 5-10 working days.
||This product is for research use only.