Neutrophil Cytosolic Factor 4 (NCF4) Antibody

Catalogue No: abx001708
Price: £120.00
(Size: 20 µl)
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Neutrophil Cytosolic Factor 4 (NCF4) Antibody Neutrophil Cytosolic Factor 4 (NCF4) Antibody Neutrophil Cytosolic Factor 4 (NCF4) Antibody Neutrophil Cytosolic Factor 4 (NCF4) Antibody Neutrophil Cytosolic Factor 4 (NCF4) Antibody

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NCF4 Antibody is a Rabbit Polyclonal antibody against NCF4. The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

Target NCF4
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human NCF4.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q15080 (UniProt, ExPASy)
UniProt Secondary AC A8K4F9, O60808, Q86U56, Q9BU98, Q9NP45
UniProt Entry Name NCF4_HUMAN
Gene Symbol NCF4
GeneID 4689
KEGG hsa:4689
String 9606.ENSP00000380334
Molecular Weight Calculated MW: 39 kDa
Observed MW: 42 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Neutrophil Cytosolic Factor 4 (NCF4) Antibody

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