Neutrophil Cytosolic Factor 4 (NCF4) Antibody

NCF4 Antibody is a Rabbit Polyclonal antibody against NCF4. The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

Target	Neutrophil Cytosolic Factor 4 (NCF4)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1-190 of human NCF4/p40-phox.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15080 (UniProt, ExPASy)
UniProt Secondary AC	A8K4F9, O60808, Q86U56, Q9BU98, Q9NP45
UniProt Entry Name	NCF4_HUMAN
Gene Symbol	NCF4
GeneID	4689
NCBI Accession	NP_038202.2
KEGG	hsa:4689
String	9606.ENSP00000380334
Molecular Weight	Calculated MW: 39 kDa Observed MW: 40 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Neutrophil Cytosolic Factor 4 (NCF4)

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