Nicastrin (NCSTN) Antibody

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Catalogue No: abx000564
Price: US$203.00
(Size: 20 µl)

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Datasheet SDS
NCSTN Antibody is a Rabbit Polyclonal antibody against NCSTN. This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.

Target Nicastrin (NCSTN)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 250-578 of human NCSTN.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q92542 (UniProt, ExPASy)
UniProt Secondary AC Q5T207, Q5T208, Q86VV5
UniProt Entry Name NICA_HUMAN
Gene Symbol NCSTN
GeneID 23385
NCBI Accession NP_056146.1
KEGG hsa:23385
String 9606.ENSP00000294785
Molecular Weight Calculated MW: 78 kDa
Observed MW: 100-120 kDa
Buffer PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Nicastrin (NCSTN)


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