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Nicastrin (NCSTN) Antibody
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Catalogue No: abx000564
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US$217.50
(Size: 20 µl)
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Datasheet SDS
NCSTN Antibody is a Rabbit Polyclonal antibody against NCSTN. This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.
Research Articles on Nicastrin (NCSTN)
| Target | Nicastrin (NCSTN) |
| Research Area | Neuroscience |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to NCSTN. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q92542 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5T207, Q5T208, Q86VV5 |
| UniProt Entry Name | NICA_HUMAN |
| Gene Symbol | NCSTN |
| GeneID | 23385 |
| NCBI Accession | NP_056146.1 |
| KEGG | hsa:23385 |
| String | 9606.ENSP00000294785 |
| Molecular Weight | Calculated MW: 78 kDa Observed MW: 100-120 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |