E3 Ubiquitin-Protein Ligase NEDD4-Like (NEDD4L) Antibody
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Catalogue No: abx028438
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US$326.25
(Size: 80 µl)
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Datasheet SDS
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK.
Research Articles on E3 Ubiquitin-Protein Ligase NEDD4-Like (NEDD4L)
| Target | E3 Ubiquitin-Protein Ligase NEDD4-Like (NEDD4L) |
| Clonality | Polyclonal |
| Reactivity | Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 576-604 amino acids from the Central region of human NEDD4L. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q96PU5 (UniProt, ExPASy) |
| UniProt Entry Name | NED4L_HUMAN |
| Gene Symbol | NEDD4L |
| GeneID | 23327 |
| OMIM | 606384 |
| HGNC | 7728 |
| KEGG | hsa:23327 |
| Ensembl | ENSG00000049759 |
| String | 9606.ENSP00000383199 |
| Molecular Weight | Calculated MW: 112 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |