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Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) Antibody
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Catalogue No: abx026692
Price:
US$290.00
(Size: 80 µl)
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NEDD8 is a ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
Research Articles on Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8)
| Target | Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1-32 amino acids from the N-terminal region of human NEDD8. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q15843 (UniProt, ExPASy) |
| UniProt Secondary AC | Q3SXN8, Q6LES6 |
| UniProt Entry Name | NEDD8_HUMAN |
| KEGG | hsa:4738 |
| String | 9606.ENSP00000250495 |
| Molecular Weight | Calculated MW: 9.07 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow and Rabbit NEDD8. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
