Neurofilament, Light Polypeptide (NEFL) Antibody

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains.Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber.They may also play a role in intracellular transport to axons and dendrites.This gene encodes the light chain neurofilament protein.Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies.A pseudogene has been identified on chromosome Y.

Target	Neurofilament, Light Polypeptide (NEFL)
Clonality	Monoclonal
Clone	O993
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human NEFL expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P07196 (UniProt, ExPASy)
UniProt Secondary AC	B9ZVN2, Q16154, Q8IU72
UniProt Entry Name	NFL_HUMAN
Gene Symbol	NEFL
GeneID	4747
OMIM	162280
HGNC	7739
KEGG	hsa:4747
Ensembl	ENSG00000277586
String	9606.ENSP00000482169
Molecular Weight	62 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Neurofilament, Light Polypeptide (NEFL)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue