Neurofilament, Light Polypeptide (NEFL) Antibody

NEFL Antibody is a Rabbit Polyclonal antibody against NEFL. Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

Target	Neurofilament, Light Polypeptide (NEFL)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human Neurofilament L.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P07196 (UniProt, ExPASy)
UniProt Secondary AC	B9ZVN2, Q16154, Q8IU72
UniProt Entry Name	NFL_HUMAN
Gene Symbol	NEFL
GeneID	4747
NCBI Accession	NP_006149.2
KEGG	hsa:4747
String	9606.ENSP00000482169
Molecular Weight	Calculated MW: 62 kDa Observed MW: 70 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Neurofilament, Light Polypeptide (NEFL)

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