Nephrin (pY1210) Antibody

This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

Target	Nephrin (pY1210)
Clonality	Polyclonal
Target Modification	Tyr1210
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, DB
Host	Rabbit
Recommended dilutions	DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1210 of human Nephrin.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O60500 (UniProt, ExPASy)
UniProt Secondary AC	A6NDH2, C3RX61
UniProt Entry Name	NPHN_HUMAN
KEGG	hsa:4868
String	9606.ENSP00000368190
Molecular Weight	Calculated MW: 135 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Nephrin (pY1210)

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