Nuclear Factor NF-Kappa-B P105 Subunit (NFKB1) Antibody
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Catalogue No: abx011949
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US$427.75
(Size: 100 µl)
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Datasheet SDS
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF- kappa -B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
Research Articles on Nuclear Factor NF-Kappa-B P105 Subunit (NFKB1)
| Target | Nuclear Factor NF-Kappa-B P105 Subunit (NFKB1) |
| Research Area | Signal Transduction, Reproductive Science |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human NFKB1 expressed in E. coli. |
| Isotype | IgG2a |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P19838 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K5Y5, B3KVE8, Q68D84, Q86V43, Q8N4X7, Q9NZC0 |
| UniProt Entry Name | NFKB1_HUMAN |
| Gene Symbol | NFKB1 |
| GeneID | 4790 |
| OMIM | 164011 |
| HGNC | 7794 |
| KEGG | hsa:4790 |
| Ensembl | ENSG00000109320 |
| String | 9606.ENSP00000226574 |
| Molecular Weight | 50-105 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |