+44 (0) 1223 755950
+1 832 327 7413
NACHT, LRR And PYD Domains-Containing Protein 3 (NLRP3) Antibody
REQUEST MORE INFO
Catalogue No: abx034000
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
(
Click on the image to see the image legend
Add to Cart
Buy It Now
GET A QUOTE
Documents
Datasheet SDS
NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis.
Research Articles on NACHT, LRR And PYD Domains-Containing Protein 3 (NLRP3)
| Target | NACHT, LRR And PYD Domains-Containing Protein 3 (NLRP3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000 - 1/2000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 65-91 amino acids from the N-terminal region of human NLRP3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q96P20 (UniProt, ExPASy) |
| UniProt Entry Name | NLRP3_HUMAN |
| Gene Symbol | NLRP3 |
| NCBI Accession | NP_001073289.1 NP_001120933.1 NP_001120934.1 NP_001230062.1 NP_004886.3 NP_899632.1 |
| KEGG | hsa:114548 |
| String | 9606.ENSP00000337383 |
| Molecular Weight | Calculated MW: 118 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |