Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) Antibody

Catalogue No: abx000900
Price: £120.00
(Size: 20 µl)
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NOTCH3 Antibody is a Rabbit Polyclonal antibody against NOTCH3. NOTCH3 belongs to the NOTCH family. It functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH3 affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The antibody is specific to NOTCH3.

Target Neurogenic Locus Notch Homolog Protein 3 (NOTCH3)
Clonality Polyclonal
Reactivity Mouse, Rat
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 751-850 of human NOTCH3.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9UM47 (UniProt, ExPASy)
UniProt Secondary AC Q9UEB3, Q9UPL3, Q9Y6L8
UniProt Entry Name NOTC3_HUMAN
Gene Symbol NOTCH3
GeneID 4854
NCBI Accession NP_000426.2
String 9606.ENSP00000263388
Molecular Weight Calculated MW: 243 kDa
Observed MW: Refer to figures
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 3.36 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Neurogenic Locus Notch Homolog Protein 3 (NOTCH3)

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