Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) Antibody

Catalogue No: abx002237
Price: £120.00
(Size: 20 µl)
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Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) Antibody Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) Antibody

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NOTCH3 Antibody is a Rabbit Polyclonal antibody against NOTCH3. This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Target NOTCH3
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/200 - 1/1000, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human NOTCH3.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9UM47 (UniProt, ExPASy)
UniProt Secondary AC Q9UEB3, Q9UPL3, Q9Y6L8
UniProt Entry Name NOTC3_HUMAN
Gene Symbol NOTCH3
GeneID 4854
String 9606.ENSP00000263388
Molecular Weight Calculated MW: 243 kDa
Observed MW: 250 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) Antibody

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