Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) Antibody

NOTCH3 Antibody is a Rabbit Polyclonal antibody against NOTCH3. This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Target	Neurogenic Locus Notch Homolog Protein 3 (NOTCH3)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/200 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1520-1640 of human NOTCH3.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UM47 (UniProt, ExPASy)
UniProt Secondary AC	Q9UEB3, Q9UPL3, Q9Y6L8
UniProt Entry Name	NOTC3_HUMAN
Gene Symbol	NOTCH3
GeneID	4854
NCBI Accession	NP_000426.2
String	9606.ENSP00000263388
Molecular Weight	Calculated MW: 244 kDa Observed MW: 90/280 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Neurogenic Locus Notch Homolog Protein 3 (NOTCH3)

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