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NPC Intracellular Cholesterol Transporter 1 (NPC1) Antibody
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Catalogue No: abx015944
Price:
US$427.75
(Size: 100 µl)
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This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain.It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus.This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol.Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
Research Articles on NPC Intracellular Cholesterol Transporter 1 (NPC1)
| Target | NPC Intracellular Cholesterol Transporter 1 (NPC1) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human NPC1 (AA: 34-174) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O15118 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DET3, Q9P130 |
| UniProt Entry Name | NPC1_HUMAN |
| Gene Symbol | NPC1 |
| GeneID | 4864 |
| OMIM | 257220 |
| HGNC | 7897 |
| KEGG | hsa:4864 |
| Ensembl | ENSG00000141458 |
| String | 9606.ENSP00000269228 |
| Molecular Weight | 142.2 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |