NPHS1, Nephrin (NPHS1) Antibody

Catalogue No: abx002201
Price: £120.00
(Size: 20 µl)

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Datasheet SDS
NPHS1 Antibody is a Rabbit Polyclonal antibody against NPHS1. This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes. In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180-kDa protein in lysates of human glomeruli and a 150-kDa protein in transfected COS-7 cell lysates.

Target NPHS1
Clonality Polyclonal
Reactivity Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/100, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human NPHS1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O60500 (UniProt, ExPASy)
UniProt Secondary AC A6NDH2, C3RX61
UniProt Entry Name NPHN_HUMAN
Gene Symbol NPHS1
GeneID 4868
KEGG hsa:4868
String 9606.ENSP00000368190
Molecular Weight Calculated MW: 130 kDa, 134 kDa
Observed MW: 135 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on NPHS1

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