NAD(P)H Dehydrogenase, Quinone 1 (NQO1) Antibody

NQO1 Antibody is a Rabbit Polyclonal antibody against NQO1. This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Target	NAD(P)H Dehydrogenase, Quinone 1 (NQO1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/100 - 1/500, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human NQO1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P15559 (UniProt, ExPASy)
UniProt Secondary AC	B2R5Y9, B4DNM7, B7ZAD1, Q86UK1
Gene Symbol	NQO1
GeneID	1728
NCBI Accession	NP_000894.1
Molecular Weight	Calculated MW: 31 kDa Observed MW: 31 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on NAD(P)H Dehydrogenase, Quinone 1 (NQO1)

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