NQO1 Antibody is a Rabbit Polyclonal antibody against NQO1. This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
| Target |
NQO1 |
| Clonality |
Polyclonal |
| Reactivity |
Human, Mouse |
| Tested Applications |
WB |
| Host |
Rabbit |
| Recommended dilutions |
WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation |
Unconjugated |
| Immunogen |
A synthetic peptide of human NQO1. |
| Isotype |
IgG |
| Form |
Liquid |
| Purification |
Affinity purified. |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC |
P15559 (UniProt,
ExPASy)
|
| UniProt Secondary AC |
B2R5Y9, B4DNM7, B7ZAD1, Q86UK1 |
| Gene Symbol |
NQO1 |
| GeneID |
1728
|
| Molecular Weight |
Calculated MW: 26 kDa, 27 kDa, 30 kDa
Observed MW: 32 kDa |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration |
> 1 mg/ml |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
Research Articles on NAD(P)H Dehydrogenase [quinone] 1 (NQO1) Antibody
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