Nuclear Receptor Subfamily 0 Group B Member 2 (NR0B2) Antibody

NR0B2 Antibody is a Rabbit Polyclonal antibody against NR0B2. The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

Target	Nuclear Receptor Subfamily 0 Group B Member 2 (NR0B2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/100 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-257 of human SHP/NR0B2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15466 (UniProt, ExPASy)
UniProt Secondary AC	F1D8P5, Q5QP36
UniProt Entry Name	NR0B2_HUMAN
Gene Symbol	NR0B2
GeneID	8431
NCBI Accession	NP_068804.1
KEGG	hsa:8431
String	9606.ENSP00000254227
Molecular Weight	Calculated MW: 28 kDa Observed MW: 28 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	2.04 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Nuclear Receptor Subfamily 0 Group B Member 2 (NR0B2)

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