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Nuclear Receptor Subfamily 0 Group B Member 2 (NR0B2) Antibody
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Catalogue No: abx001518
Price:
£120.00
(Size: 20 µl)
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NR0B2 Antibody is a Rabbit Polyclonal antibody against NR0B2. The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Research Articles on NR0B2
| Target | NR0B2 |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-257 of human NR0B2 (NP_068804.1). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q15466 (UniProt, ExPASy) |
| UniProt Secondary AC | F1D8P5, Q5QP36 |
| UniProt Entry Name | NR0B2_HUMAN |
| Gene Symbol | NR0B2 |
| GeneID | 8431 |
| NCBI Accession | NP_068804.1 |
| KEGG | hsa:8431 |
| String | 9606.ENSP00000254227 |
| Molecular Weight | Calculated MW: 28 kDa Observed MW: 28 kDa |
| Buffer | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration | 2.04 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
