Oxysterols Receptor LXR-Alpha (NR1H3) Antibody
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Catalogue No: abx034585
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US$326.25
(Size: 80 µl)
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Datasheet SDS
NR1H3 form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible NR1H3 is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements.
Research Articles on Oxysterols Receptor LXR-Alpha (NR1H3)
| Target | Oxysterols Receptor LXR-Alpha (NR1H3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IF/ICC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 226-253 amino acids from the Central region of human NR1H3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13133 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K3J9, D3DQR1, Q8IW13, Q96H87 |
| UniProt Entry Name | NR1H3_HUMAN |
| Gene Symbol | NR1H3 |
| GeneID | 10062 |
| OMIM | 602423 |
| HGNC | 7966 |
| KEGG | hsa:10062 |
| Ensembl | ENSG00000025434 |
| String | 9606.ENSP00000477707 |
| Molecular Weight | Calculated MW: 50.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |