Oxysterols Receptor LXR-Alpha (NR1H3) Antibody

NR1H3 Antibody is a Rabbit Polyclonal antibody against NR1H3. The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

Target	Oxysterols Receptor LXR-Alpha (NR1H3)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 160-230 of human LXRα.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13133 (UniProt, ExPASy)
UniProt Secondary AC	A8K3J9, D3DQR1, Q8IW13, Q96H87
UniProt Entry Name	NR1H3_HUMAN
Gene Symbol	NR1H3
GeneID	10062
NCBI Accession	NP_005684.2
KEGG	hsa:10062
String	9606.ENSP00000477707
Molecular Weight	Calculated MW: 50 kDa Observed MW: 50 kDa
Buffer	PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Oxysterols Receptor LXR-Alpha (NR1H3)

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