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Oxysterols Receptor LXR-Alpha (NR1H3) Antibody
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Catalogue No: abx001753
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US$348.00
(Size: 60 µl)
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Datasheet SDS
NR1H3 Antibody is a Rabbit Polyclonal antibody against NR1H3. The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Research Articles on Oxysterols Receptor LXR-Alpha (NR1H3)
| Target | Oxysterols Receptor LXR-Alpha (NR1H3) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human LXR alpha |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13133 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K3J9, D3DQR1, Q8IW13, Q96H87 |
| UniProt Entry Name | NR1H3_HUMAN |
| Gene Symbol | NR1H3 |
| GeneID | 10062 |
| OMIM | 602423 |
| NCBI Accession | NP_005684.2 |
| HGNC | 7966 |
| KEGG | hsa:10062 |
| Ensembl | ENSG00000025434 |
| String | 9606.ENSP00000477707 |
| Molecular Weight | Calculated MW: 43 kDa/45 kDa/50 kDa Observed MW: 50 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
