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Nuclear Receptor Subfamily 1 Group I Member 3 (NR1I3) Antibody

Catalogue No: abx001605
Price: £120.00
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Nuclear Receptor Subfamily 1 Group I Member 3 (NR1I3) Antibody Nuclear Receptor Subfamily 1 Group I Member 3 (NR1I3) Antibody

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NR1I3 Antibody is a Rabbit Polyclonal antibody against NR1I3. This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Target NR1I3
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human NR1I3.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q14994 (UniProt, ExPASy)
UniProt Entry Name NR1I3_HUMAN
Gene Symbol NR1I3
GeneID 9970
KEGG hsa:9970
String 9606.ENSP00000356959
Molecular Weight Calculated MW: 30-40 kDa
Observed MW: 46 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Nuclear Receptor Subfamily 1 Group I Member 3 (NR1I3) Antibody

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