Constitutive Androstane Receptor / CAR (NR1I3) Antibody

NR1I3 Antibody is a Rabbit Polyclonal antibody against NR1I3. This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Target	Constitutive Androstane Receptor / CAR (NR1I3)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 103-352 of human NR1I3.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14994 (UniProt, ExPASy)
UniProt Entry Name	NR1I3_HUMAN
Gene Symbol	NR1I3
GeneID	9970
NCBI Accession	NP_001070948.1
KEGG	hsa:9970
String	9606.ENSP00000356959
Molecular Weight	Calculated MW: 40 kDa Observed MW: 45 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	4.09 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Constitutive Androstane Receptor / CAR (NR1I3)

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