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Mineralocorticoid Receptor (NR3C2) Antibody
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Catalogue No: abx002355
Price:
US$348.00
(Size: 60 µl)
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NR3C2 Antibody is a Rabbit Polyclonal antibody against NR3C2. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Research Articles on Mineralocorticoid Receptor (NR3C2)
| Target | Mineralocorticoid Receptor (NR3C2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human Mineralocorticoid receptor |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P08235 (UniProt, ExPASy) |
| UniProt Secondary AC | B0ZBF5, B0ZBF7, Q2NKL1, Q96KQ8, Q96KQ9 |
| UniProt Entry Name | MCR_HUMAN |
| Gene Symbol | NR3C2 |
| GeneID | 4306 |
| NCBI Accession | NP_000892.2 |
| KEGG | hsa:4306 |
| String | 9606.ENSP00000350815 |
| Molecular Weight | Calculated MW: 75 kDa/94 kDa/107 kDa Observed MW: 100 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
