Mineralocorticoid Receptor (NR3C2) Antibody

NR3C2 Antibody is a Rabbit Polyclonal antibody against NR3C2. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.

Target	Mineralocorticoid Receptor (NR3C2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 450-600 of human Mineralocorticoid receptor (NR3C2).
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08235 (UniProt, ExPASy)
UniProt Secondary AC	B0ZBF5, B0ZBF7, Q2NKL1, Q96KQ8, Q96KQ9
UniProt Entry Name	MCR_HUMAN
Gene Symbol	NR3C2
GeneID	4306
NCBI Accession	NP_000892.2
KEGG	hsa:4306
String	9606.ENSP00000350815
Molecular Weight	Calculated MW: 107 kDa Observed MW: 100 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mineralocorticoid Receptor (NR3C2)

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