Mineralocorticoid Receptor (NR3C2) Antibody

Catalogue No: abx002355
Price: £120.00
(Size: 20 µl)
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NR3C2 Antibody is a Rabbit Polyclonal antibody against NR3C2. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.

Target NR3C2
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human NR3C2.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P08235 (UniProt, ExPASy)
UniProt Secondary AC B0ZBF5, B0ZBF7, Q2NKL1, Q96KQ8, Q96KQ9
UniProt Entry Name MCR_HUMAN
Gene Symbol NR3C2
GeneID 4306
KEGG hsa:4306
String 9606.ENSP00000350815
Molecular Weight Calculated MW: 75 kDa, 94 kDa, 107 kDa
Observed MW: 107 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on NR3C2

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