Neuregulin 2 (NRG2) Antibody

Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease.

Target	Neuregulin 2 (NRG2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 358-389 amino acids from the C-terminal region of human NRG2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O14511 (UniProt, ExPASy)
UniProt Entry Name	NRG2_HUMAN
Gene Symbol	NRG2
NCBI Accession	NP_001171864.1 NP_004874.1 NP_053584.1 NP_053585.1 NP_053586.1
KEGG	hsa:9542
String	9606.ENSP00000354910
Molecular Weight	Calculated MW: 91.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat NRG2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Neuregulin 2 (NRG2)

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