RNA Cytosine C(5)-Methyltransferase NSUN2 (NSUN2) Antibody
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Catalogue No: abx025922
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu (CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu (CAA) (Brzezicha et al., 2006 [PubMed 17071714]).
Research Articles on RNA Cytosine C(5)-Methyltransferase NSUN2 (NSUN2)
| Target | RNA Cytosine C(5)-Methyltransferase NSUN2 (NSUN2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 423-451 amino acids from the Central region of human NSUN2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q08J23 (UniProt, ExPASy) |
| UniProt Entry Name | NSUN2_HUMAN |
| Gene Symbol | NSUN2 |
| GeneID | 54888 |
| OMIM | 610916 |
| HGNC | 25994 |
| KEGG | hsa:54888 |
| Ensembl | ENSG00000037474 |
| String | 9606.ENSP00000264670 |
| Molecular Weight | Calculated MW: 86.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |