7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1) Antibody
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Catalogue No: abx004194
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US$217.50
(Size: 20 µl)
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Datasheet SDS
NUDT1 Antibody is a Rabbit Polyclonal antibody against NUDT1. Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
Research Articles on 7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1)
| Target | 7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1) |
| Research Area | Drug Targets |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to NUDT1. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P36639 (UniProt, ExPASy) |
| UniProt Secondary AC | A4D205, Q6LES7, Q6P0Y6, Q7Z7N6, Q8IV95, Q9UBM0, Q9UBM9 |
| UniProt Entry Name | 8ODP_HUMAN |
| Gene Symbol | NUDT1 |
| GeneID | 4521 |
| NCBI Accession | NP_945192.1 |
| KEGG | hsa:4521 |
| String | 9606.ENSP00000380241 |
| Molecular Weight | Calculated MW: 18 kDa Observed MW: 18 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |