2'-5'-Oligoadenylate Synthetase 1 (OAS1) Antibody
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Catalogue No: abx001970
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US$348.00
(Size: 60 µl)
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Datasheet SDS
OAS1 Antibody is a Rabbit Polyclonal antibody against OAS1. This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.
Research Articles on 2'-5'-Oligoadenylate Synthetase 1 (OAS1)
| Target | 2'-5'-Oligoadenylate Synthetase 1 (OAS1) |
| Research Area | Enzymes and Kinases |
| Clonality | Polyclonal |
| Reactivity | Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to human OAS1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P00973 (UniProt, ExPASy) |
| UniProt Entry Name | OAS1_HUMAN |
| Gene Symbol | OAS1 |
| GeneID | 4938 |
| NCBI Accession | NP_058132.2 |
| KEGG | hsa:4938 |
| String | 9606.ENSP00000388001 |
| Molecular Weight | Calculated MW: 41 kDa/43 kDa/46 kDa/47 kDa Observed MW: 46 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
