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2'-5'-Oligoadenylate Synthetase 1 (OAS1) Antibody

Catalogue No: abx001970
Price: £120.00
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2'-5'-Oligoadenylate Synthetase 1 (OAS1) Antibody 2'-5'-Oligoadenylate Synthetase 1 (OAS1) Antibody

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OAS1 Antibody is a Rabbit Polyclonal antibody against OAS1. This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

Target 2'-5'-Oligoadenylate Synthetase 1 (OAS1)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human OAS1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P00973 (UniProt, ExPASy)
UniProt Entry Name OAS1_HUMAN
Gene Symbol OAS1
GeneID 4938
KEGG hsa:4938
String 9606.ENSP00000388001
Molecular Weight Calculated MW: 41 kDa, 43 kDa, 46 kDa, 47 kDa
Observed MW: 40 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on 2'-5'-Oligoadenylate Synthetase 1 (OAS1) Antibody

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