2'-5'-Oligoadenylate Synthase-Like Protein (OASL) Antibody

2-prime, 5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.

Target	2'-5'-Oligoadenylate Synthase-Like Protein (OASL)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 484-514 amino acids from the C-terminal region of human OASL.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15646 (UniProt, ExPASy)
UniProt Secondary AC	B2RAZ2, I1YDD2, O75686, Q17R95, Q9Y6K6, Q9Y6K7
UniProt Entry Name	OASL_HUMAN
NCBI Accession	NP_001248754.1 NP_003724.1 NP_937856.1
KEGG	hsa:8638
String	9606.ENSP00000257570
Molecular Weight	Calculated MW: 59.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 2'-5'-Oligoadenylate Synthase-Like Protein (OASL)

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