POU Class 5 Homeobox 1 / OCT4 (POU5F1) Antibody

This gene encodes a transcription factor containing a POU homeodomain.This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency.A translocation of this gene with the Ewing's sarcoma gene, t (6;22) (p21;q12), has been linked to tumor formation.Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon.Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. (provided by RefSeq).Tissue specificity: Expressed in developing brain.Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum.Low levels of expression in adult tissues.

Target	POU Class 5 Homeobox 1 / OCT4 (POU5F1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Synthesized peptide derived from internal of human Oct4.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q01860 (UniProt, ExPASy)
UniProt Entry Name	PO5F1_HUMAN
Gene Symbol	POU5F1
GeneID	5460
OMIM	164177
HGNC	9221
KEGG	hsa:5460
Ensembl	ENSG00000204531
String	9606.ENSP00000259915
Molecular Weight	45 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on POU Class 5 Homeobox 1 / OCT4 (POU5F1)

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