Mu-Type Opioid Receptor (OPRM1) Antibody

OPRM1 is the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin (see POMC, MIM 176830) and the enkephalins (see PENK, MIM 131330). The OPRM1 receptor is a membrane of the G protein-coupled receptor family (Bond et al., 1998 [PubMed 9689128]). There are at least 3 types of opioid receptors, mu, kappa (OPRK1; MIM 165196), and delta, each with a distinct pharmacologic profile.

Target	Mu-Type Opioid Receptor (OPRM1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 161-187 amino acids from the Central region of human OPRM1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35372 (UniProt, ExPASy)
UniProt Entry Name	OPRM_HUMAN
Gene Symbol	OPRM1
GeneID	4988
KEGG	hsa:4988
String	9606.ENSP00000394624
Molecular Weight	Calculated MW: 44.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat, Pig and Monkey OPRM1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mu-Type Opioid Receptor (OPRM1)

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