Optineurin (OPTN) Antibody

OPTN Antibody is a Rabbit Polyclonal antibody against OPTN. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Target	Optineurin (OPTN)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IHC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IP: 0.5-4 µg/25-100 µg whole cell extracts. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-577 of human OPTN.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q96CV9 (UniProt, ExPASy)
UniProt Entry Name	OPTN_HUMAN
Gene Symbol	OPTN
GeneID	10133
NCBI Accession	NP_068815.2
KEGG	hsa:10133
String	9606.ENSP00000368022
Molecular Weight	Calculated MW: 66 kDa Observed MW: 78 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Optineurin (OPTN)

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