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Cyclin-Dependent Kinase Inhibitor 2A Phospho-Ser7 (CDKN2A pS7) Antibody
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Catalogue No: abx031885
Price:
US$326.25
(Size: 80 µl)
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Datasheet SDS
This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. CDKN2A functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. This protein acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. The gene for this protein is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Research Articles on Cyclin-Dependent Kinase Inhibitor 2A Phospho-Ser7 (CDKN2A pS7)
| Target | Cyclin-Dependent Kinase Inhibitor 2A Phospho-Ser7 (CDKN2A pS7) |
| Research Area | Tumor Immunity, Developmental Science |
| Clonality | Polyclonal |
| Target Modification | Ser7 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/100 - 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S7 of human Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P42771 (UniProt, ExPASy) |
| UniProt Entry Name | CDN2A_HUMAN |
| Gene Symbol | CDKN2A |
| GeneID | 1029 |
| NCBI Accession | NP_000068.1 NP_001182061.1 NP_478104.2 |
| KEGG | hsa:1029 |
| String | 9606.ENSP00000418915 |
| Molecular Weight | Calculated MW: 16.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Please enquire. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |