Protein Disulfide-Isomerase / PDI (P4HB) Antibody
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Catalogue No: abx031784
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US$326.25
(Size: 80 µl)
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Datasheet SDS
P4HB is a highly abundant multifunctional enzyme that belongs to the Protein Disulfide-Isomerase / PDI family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
Research Articles on Protein Disulfide-Isomerase / PDI (P4HB)
| Target | Protein Disulfide-Isomerase / PDI (P4HB) |
| Research Area | Enzymes and Kinases |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 436-464 amino acids from the C-terminal region of human P4HB. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P07237 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RDQ2, P30037, P32079, Q15205, Q6LDE5 |
| UniProt Entry Name | PDIA1_HUMAN |
| Gene Symbol | P4HB |
| GeneID | 5034 |
| OMIM | 112240 |
| HGNC | 8548 |
| KEGG | hsa:5034 |
| Ensembl | ENSG00000185624 |
| String | 9606.ENSP00000327801 |
| Molecular Weight | Calculated MW: 57.1 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow and Hamster P4HB. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |