Protein Disulfide-Isomerase (P4HB) Antibody

P4HB Antibody is a Rabbit Polyclonal antibody against P4HB. This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.

Target	Protein Disulfide-Isomerase (P4HB)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/100, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 329-508 of human P4HB.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P07237 (UniProt, ExPASy)
UniProt Secondary AC	B2RDQ2, P30037, P32079, Q15205, Q6LDE5
UniProt Entry Name	PDIA1_HUMAN
Gene Symbol	P4HB
GeneID	5034
NCBI Accession	NP_000909.2
KEGG	hsa:5034
String	9606.ENSP00000327801
Molecular Weight	Calculated MW: 57 kDa Observed MW: 57 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein Disulfide-Isomerase (P4HB)

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