Protein Disulfide-Isomerase / PDI (P4HB) Antibody
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Catalogue No: abx000827
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US$217.50
(Size: 20 µl)
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Datasheet SDS
P4HB Antibody is a Rabbit Polyclonal antibody against P4HB. This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the Protein Disulfide-Isomerase / PDI family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
Research Articles on Protein Disulfide-Isomerase / PDI (P4HB)
| Target | Protein Disulfide-Isomerase / PDI (P4HB) |
| Research Area | Enzymes and Kinases |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/100, IP: 0.5 µg - 4 µg antibody per 200 µg - 400 µg extracts of whole cells. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 329-508 of human P4HB. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P07237 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RDQ2, P30037, P32079, Q15205, Q6LDE5 |
| UniProt Entry Name | PDIA1_HUMAN |
| Gene Symbol | P4HB |
| GeneID | 5034 |
| OMIM | 112240 |
| NCBI Accession | NP_000909.2 |
| HGNC | 8548 |
| KEGG | hsa:5034 |
| Ensembl | ENSG00000185624 |
| String | 9606.ENSP00000327801 |
| Molecular Weight | Calculated MW: 57 kDa Observed MW: 57 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |