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Introduction | Tumor Antigen P53 (TP53), also known as p53, is a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. |
Target | Cellular Tumor Antigen P53 (TP53) |
Reactivity | Human, Mouse, Rat |
Tested Applications | ELISA |
Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
Validity | 6 months. |
UniProt Primary AC | P04637 (UniProt, ExPASy) |
UniProt Entry Name | P53_HUMAN |
Gene Symbol | TP53 |
GeneID | 7157 |
OMIM | 133239 |
HGNC | 11998 |
KEGG | hsa:7157 |
Ensembl | ENSG00000141510 |
String | 9606.ENSP00000269305 |
Detection Method | Colorimetric |
Plate Coating | Uncoated |
Substrate | TMB |
Detection Antibody Conjugation | HRP |
Availability | Shipped within 1-2 weeks. |
Note | This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |