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Tumor Protein 63 alpha (TP63-alpha) Antibody
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Catalogue No: abx011670
Price:
US$427.75
(Size: 100 µl)
Orders to United States ship from United States
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Tumor Protein 63 alpha (TP63-alpha) / p63 alpha antibody is a Mouse monoclonal against Tumor Protein 63 alpha (TP63a). The p63 gene (TP63) is a homologue of the p53 tumor suppressor gene. Like p53, p63 contains a transactivation (TA) domain induce the transcription of target genes, a DNA binding domain, and an oligomerization domain (OD), used to form tetramers. In contrast to p53, the p63 gene encodes for at least six major isotypes. Three isotypes (TAp63 alpha, TAp63 beta, and TAp63 gamma) contain the transactivating (TA) domain and are able to transactivate p53 report genes and induce apoptosis. The other three isotypes (delta Np63 alpha, delta Np63 beta, delta Np63 gamma) are transcribed from an internal promoter localized within intron 3 and lack the TA domain. They act as dominant-negatives to suppress transactivation by both p53 and TAp63 isotypes. p63 is highly expressed in the basal cells of the epithelium significant for proper limb outgrowth and morphogenesis. In differentiating tissues, p63 is crucial for maintaining the stem cell identity of the basal cells, and is indispensable for correct development of the skin as well as the limb. p63-deficient mice lack all squamous epithelia and their derivatives, including hair, whiskers, teeth, as well as mammary, lacrimal, and salivary glands.Tissue specificity: Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of delta N-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.
Research Articles on Tumor Protein 63 alpha (TP63-alpha)
| Target | Tumor Protein 63 alpha (TP63-alpha) |
| Research Area | Tumor Immunity |
| Clonality | Monoclonal |
| Clone | I504 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Tested Applications | ELISA, WB, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Synthesized peptide corresponding to Human Tumor Protein 63 alpha (TP63-alpha). |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9H3D4 (UniProt, ExPASy) |
| UniProt Entry Name | P63_HUMAN |
| Gene Symbol | TP63 |
| GeneID | 8626 |
| Molecular Weight | Calculated MW: 51 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |