Polyadenylate-Binding Protein 2 (PABPN1) Antibody

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly (A) tails. The protein is required for progressive and efficient polymerization of poly (A) tails on the 3' ends of eukaryotic genes and controls the size of the poly (A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly (A) binding protein is localized in the cytoplasm. An expansion of the trinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end of the coding region of this gene leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Multiple splice variants have been described but their full-length nature is not known. One splice variant includes introns 1 and 6 but no protein is formed.

Target	Polyadenylate-Binding Protein 2 (PABPN1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 270-298 amino acids from the C-terminal region of human PABPN1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q86U42 (UniProt, ExPASy)
UniProt Secondary AC	D3DS49, O43484
UniProt Entry Name	PABP2_HUMAN
Gene Symbol	PABPN1
KEGG	hsa:8106
String	9606.ENSP00000216727
Molecular Weight	Calculated MW: 32.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow PABPN1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Polyadenylate-Binding Protein 2 (PABPN1)

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