Polyadenylate-Binding Protein 2 (PABPN1) Antibody

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Catalogue No: abx004649
Price: US$203.00
(Size: 20 µl)

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Datasheet SDS
PABPN1 Antibody is a Rabbit Monoclonal antibody against PABPN1. This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.

Target Polyadenylate-Binding Protein 2 (PABPN1)
Clonality Monoclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PABPN1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q86U42 (UniProt, ExPASy)
UniProt Secondary AC D3DS49, O43484
UniProt Entry Name PABP2_HUMAN
Gene Symbol PABPN1
GeneID 8106
NCBI Accession NP_004634.1
KEGG hsa:8106
String 9606.ENSP00000216727
Molecular Weight Calculated MW: 33 kDa
Observed MW: 45 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Polyadenylate-Binding Protein 2 (PABPN1)


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