Protease Activated Receptor 4 (PAR4) Antibody

Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis.It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults.Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration.The tumor suppressor WT1 represses and activates transcription.The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor.Par4 is a WT1 interacting protein that also functions as a transcriptional repressor.

Target	Protease Activated Receptor 4 (PAR4)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of PAR4 (aa1-330) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q96IZ0 (UniProt, ExPASy)
UniProt Secondary AC	O75796, Q6FHY9, Q8N700
UniProt Entry Name	PAWR_HUMAN
Gene Symbol	PAWR
GeneID	5074
OMIM	601936
HGNC	8614
KEGG	hsa:5074
Ensembl	ENSG00000177425
String	9606.ENSP00000328088
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protease Activated Receptor 4 (PAR4)

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