Proteinase-Activated Receptor 4 (F2RL3) Antibody
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Catalogue No: abx016047
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US$427.75
(Size: 100 µl)
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Datasheet SDS
Prostate apoptosis response 4 (F2RL3) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis.It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults.F2RL3 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration.The tumor suppressor WT1 represses and activates transcription.The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor.F2RL3 is a WT1 interacting protein that also functions as a transcriptional repressor.
Research Articles on Proteinase-Activated Receptor 4 (F2RL3)
| Target | Proteinase-Activated Receptor 4 (F2RL3) |
| Research Area | Hematology |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of PAR4 (aa1-330) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q96IZ0 (UniProt, ExPASy) |
| UniProt Secondary AC | O75796, Q6FHY9, Q8N700 |
| UniProt Entry Name | PAWR_HUMAN |
| Gene Symbol | PAWR |
| GeneID | 5074 |
| OMIM | 601936 |
| HGNC | 8614 |
| KEGG | hsa:5074 |
| Ensembl | ENSG00000177425 |
| String | 9606.ENSP00000328088 |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |