E3 Ubiquitin-Protein Ligase Parkin (PRKN) Antibody

PRKN Antibody is a Rabbit Polyclonal antibody against PRKN. The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Target	E3 Ubiquitin-Protein Ligase Parkin (PRKN)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 81-280 of human Parkin.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O60260 (UniProt, ExPASy)
UniProt Entry Name	PRKN_HUMAN
Gene Symbol	PRKN
GeneID	5071
OMIM	168600
NCBI Accession	NP_004553.2
HGNC	8607
KEGG	hsa:5071
Ensembl	ENSG00000185345
String	9606.ENSP00000355865
Molecular Weight	Calculated MW: 52 kDa Observed MW: 52 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on E3 Ubiquitin-Protein Ligase Parkin (PRKN)

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