E3 Ubiquitin-Protein Ligase Parkin (PRKN) Antibody
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Catalogue No: abx000921
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US$217.50
(Size: 20 µl)
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Datasheet SDS
PRKN Antibody is a Rabbit Polyclonal antibody against PRKN. The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
Research Articles on E3 Ubiquitin-Protein Ligase Parkin (PRKN)
| Target | E3 Ubiquitin-Protein Ligase Parkin (PRKN) |
| Research Area | Neuroscience |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 81-280 of Human E3 Ubiquitin-Protein Ligase Parkin. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O60260 (UniProt, ExPASy) |
| UniProt Secondary AC | A3FG77, A8K975, D3JZW7, D3K2X0, Q5TFV8, Q5VVX4, Q6Q2I6, Q8NI41, Q8NI43, Q8NI44, Q8WW07 |
| UniProt Entry Name | PRKN_HUMAN |
| Gene Symbol | PRKN |
| GeneID | 5071 |
| OMIM | 168600 |
| NCBI Accession | NP_004553.2 |
| HGNC | 8607 |
| KEGG | hsa:5071 |
| Ensembl | ENSG00000185345 |
| String | 9606.ENSP00000355865 |
| Molecular Weight | Calculated MW: 52 kDa Observed MW: 52 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | 2.18 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |