Poly A Specific Ribonuclease (PARN) Antibody

PARN Antibody is a Rabbit Polyclonal antibody against PARN. The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	Poly A Specific Ribonuclease (PARN)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PARN.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O95453 (UniProt, ExPASy)
UniProt Secondary AC	B2RCB3, B4DDG8, B4DSB0, B4DWR4, B4E1H6
UniProt Entry Name	PARN_HUMAN
Gene Symbol	PARN
GeneID	5073
NCBI Accession	NP_002573.1
KEGG	hsa:5073
String	9606.ENSP00000387911
Molecular Weight	Calculated MW: 73 kDa Observed MW: 73 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Poly A Specific Ribonuclease (PARN)

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