Poly ADP Ribose Polymerase (PARP) Antibody

This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl)transferase, which modifies various nuclear proteins by poly (ADP-ribosyl)ation.The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage.In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Target	Poly ADP Ribose Polymerase (PARP)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Synthetic peptide of human PARP, conjugated to KLH.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P09874 (UniProt, ExPASy)
UniProt Secondary AC	B1ANJ4, Q8IUZ9
UniProt Entry Name	PARP1_HUMAN
Gene Symbol	PARP1
GeneID	142
OMIM	173870
HGNC	270
KEGG	hsa:142
Ensembl	ENSG00000143799
String	9606.ENSP00000355759
Molecular Weight	117 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Poly ADP Ribose Polymerase (PARP)

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