Poly ADP Ribose Polymerase 6 (Parp6) Antibody

Poly (ADP-ribosyl) ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly (ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly (ADP-ribosyl) ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.

Target	Poly ADP Ribose Polymerase 6 (Parp6)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 553-583 amino acids from the C-terminal region of human Parp6.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q2NL67 (UniProt, ExPASy)
UniProt Secondary AC	Q9H7C5, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4
UniProt Entry Name	PARP6_HUMAN
KEGG	hsa:56965
String	9606.ENSP00000456348
Molecular Weight	Calculated MW: 71.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse PARP6.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Poly ADP Ribose Polymerase 6 (Parp6)

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