Paired Box Protein Pax-5 (PAX5) Antibody

This gene encodes a member of the paired box (PAX) family of transcription factors.The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box.PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation.This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation.Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis.This gene is located at 9p13, which is involved in t (9;14) (p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas.This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas.Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Target	Paired Box Protein Pax-5 (PAX5)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q02548 (UniProt, ExPASy)
UniProt Entry Name	PAX5_HUMAN
Gene Symbol	PAX5
GeneID	5079
OMIM	167414
HGNC	8619
KEGG	hsa:5079
Ensembl	ENSG00000196092
String	9606.ENSP00000350844
Molecular Weight	45 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Paired Box Protein Pax-5 (PAX5)

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