Paired Box Protein Pax-8 (PAX8) Antibody

PAX8 Antibody is a Rabbit Polyclonal antibody against PAX8. PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX8 has 5 isoforms with calculated MW 31kd, 34kd, 41kd, 43kd and 48kd. And there is a 60kd band corresponding to the electrophoretic mobility of PAX8 (PMID:15650356). Proteintech’s 10336-1-AP antibody has cross-reactivities with the other PAX family members.

Target	Paired Box Protein Pax-8 (PAX8)
Clonality	Polyclonal
Reactivity	Human, Mouse , Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PAX8.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q06710 (UniProt, ExPASy)
UniProt Secondary AC	Q09155, Q16337, Q16338, Q16339, Q4ZG35, Q96J49
UniProt Entry Name	PAX8_HUMAN
Gene Symbol	PAX8
GeneID	7849
NCBI Accession	NP_003457.1
KEGG	hsa:7849
String	9606.ENSP00000263334
Molecular Weight	Calculated MW: 48 kDa Observed MW: 48 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Paired Box Protein Pax-8 (PAX8)

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