Pre-B-Cell Leukemia Transcription Factor 1 (PBX1) Antibody
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Catalogue No: abx000562
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US$348.00
(Size: 60 µl)
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Datasheet SDS
PBX1 Antibody is a Rabbit Polyclonal antibody against PBX1. This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Articles on Pre-B-Cell Leukemia Transcription Factor 1 (PBX1)
| Target | Pre-B-Cell Leukemia Transcription Factor 1 (PBX1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human PBX1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P40424 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DSC1, F5H4U9, Q5T488 |
| UniProt Entry Name | PBX1_HUMAN |
| Gene Symbol | PBX1 |
| GeneID | 5087 |
| NCBI Accession | NP_002576.1 |
| KEGG | hsa:5087 |
| String | 9606.ENSP00000405890 |
| Molecular Weight | Calculated MW: 38 kDa/46 kDa Observed MW: 47 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-7 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
