Pre-B-Cell Leukemia Transcription Factor 1 (PBX1) Antibody

PBX1 Antibody is a Rabbit Polyclonal antibody against PBX1. This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	Pre-B-Cell Leukemia Transcription Factor 1 (PBX1)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PBX1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P40424 (UniProt, ExPASy)
UniProt Secondary AC	B4DSC1, F5H4U9, Q5T488
UniProt Entry Name	PBX1_HUMAN
Gene Symbol	PBX1
GeneID	5087
NCBI Accession	NP_002576.1
KEGG	hsa:5087
String	9606.ENSP00000405890
Molecular Weight	Calculated MW: 47 kDa Observed MW: 50 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Pre-B-Cell Leukemia Transcription Factor 1 (PBX1)

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