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Pre-B-Cell Leukemia Transcription Factor 1 (PBX1) Antibody

Catalogue No: abx000562
Price: £120.00
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Pre-B-Cell Leukemia Transcription Factor 1 (PBX1) Antibody

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PBX1 Antibody is a Rabbit Polyclonal antibody against PBX1. This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target PBX1
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PBX1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P40424 (UniProt, ExPASy)
UniProt Secondary AC B4DSC1, F5H4U9, Q5T488
UniProt Entry Name PBX1_HUMAN
Gene Symbol PBX1
GeneID 5087
KEGG hsa:5087
String 9606.ENSP00000405890
Molecular Weight Calculated MW: 38 kDa, 46 kDa
Observed MW: 52 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Pre-B-Cell Leukemia Transcription Factor 1 (PBX1) Antibody

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