Poly(RC) Binding Protein 1 (PCBP1) Antibody

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC) binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

Target	Poly(RC) Binding Protein 1 (PCBP1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 188-217 amino acids from the Central region of human PCBP1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15365 (UniProt, ExPASy)
UniProt Secondary AC	Q13157, Q14975
UniProt Entry Name	PCBP1_HUMAN
KEGG	hsa:5093
String	9606.ENSP00000305556
Molecular Weight	Calculated MW: 37.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow and Rabbit PCBP1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Poly(RC) Binding Protein 1 (PCBP1)

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