Poly(RC) Binding Protein 2 (PCBP2) Antibody
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Price:
US$203.00
(Size: 20 µl)
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PCBP2 Antibody is a Rabbit Polyclonal antibody against PCBP2. The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Target |
Poly(RC) Binding Protein 2 (PCBP2) |
Clonality |
Polyclonal |
Reactivity |
Human, Mouse, Rat |
Tested Applications |
WB, IHC, IF/ICC |
Host |
Rabbit |
Recommended dilutions |
WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human hnRNP E2/PCBP2. |
Isotype |
IgG |
Form |
Liquid |
Purification |
Purified by affinity chromatography. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
Q15366 (UniProt,
ExPASy)
|
UniProt Entry Name |
PCBP2_HUMAN |
Gene Symbol |
PCBP2 |
GeneID |
5094
|
NCBI Accession |
NP_001122383.1
|
KEGG |
hsa:5094
|
String |
9606.ENSP00000352438
|
Molecular Weight |
Calculated MW: 39 kDa Observed MW: 35-45 kDa |
Buffer |
PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
Concentration |
> 0.2 mg/ml |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on Poly(RC) Binding Protein 2 (PCBP2)