Proliferating Cell Nuclear Antigen (PCNA) Antibody

PCNA Antibody is a Rabbit Polyclonal antibody against PCNA. The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Target	Proliferating Cell Nuclear Antigen (PCNA)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 162-261 of human PCNA.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P12004 (UniProt, ExPASy)
UniProt Secondary AC	B2R897, D3DW02
UniProt Entry Name	PCNA_HUMAN
Gene Symbol	PCNA
GeneID	5111
NCBI Accession	NP_002583.1
KEGG	hsa:5111
String	9606.ENSP00000368458
Molecular Weight	Calculated MW: 29 kDa Observed MW: 34 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Proliferating Cell Nuclear Antigen (PCNA)

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